4.2 (2 reviews)

NAFLD/NASH pathophysiology and diagnosis - 30 minute course

  • ico

    24/7 available online

  • ico


  • ico


Start the module

In this self-paced e-learning module we will take a look at non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH).

After completing this pathophysiology and diagnosis e-learning module, you should be able to:

  • understand the pathological mechanisms behind NAFLD-NASH
  • understand the various means for diagnosis of NAFLD-NASH as well as their advantages and disadvantages
  • know what guidelines recommend with regards to screening

This module is created by course director Onno Holleboom (AmsterdamUMC, the Netherlands) and consists of the following topics:

  • A multi-system disease
    >Insulin resistance
    >Lipid metabolism and lipotoxicity
    >Inflammation & macrophage activation
    >Genetic factors
    ● NAFLD/NASH symptoms and signs
    ● Diagnosis
    > liver biopsy
    > Non-invasive methods
    o Biomarkers
    o NAFLD Fibrosis Score
    o Enhanced liver fibrosis (ELF) test
    o Elastography (VCTE, FibroScan, MRE)
    o Fibrosis-4 (FIB-4) test

● Screening:
> Who?
> When?
> By whom?
> Barriers to screening

Enjoyed this course? After completing the course you can sign up for updates on the upcoming educational content.


Onno Holleboom
Onno Holleboom
Internist, faculty member & Principal Investigator

Dr. Onno Holleboom MD PhD is an internist registered in Vascular Medicine and Endocrinology, faculty...

Logo LUMC Logo AmsterdamUMC Julius Clinical logo Fatty Liver Alliance logo NVE Logo Logo Elevate Health